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Not many modern brides are caught up in all of the traditions and superstitions that surround the wedding day, but just in case you are in the minority that

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

wants to assure that you’ll have the best of luck throughout your marriage, here are some age-old traditions you may want to heed.

Most everyone is familiar

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

with the saying, “Something old, something new, something borrowed, something blue.” It’s like a mantra that bride’s say as they check off the list.

* Somet

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

hing old – it is best if this is something that was owned by a happily married woman. It is believed that this will ensure the transfer of happiness.
*

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Something new – this can be anything, but is usually the gown, shoes or bridal bouquet.
* Something borrowed – traditionally, future wealth and fortune

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

will follow if the borrowed item is made of gold.
* Something blue – this color is symbolic of modesty, fidelity and love. Blue flowers can be part of t

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

e wedding bouquet, or perhaps the garter that the bride wears can be blue.

About the garter…why is it tossed following the ceremony? The garter is worn on t

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

he right leg of the bride, just above the knee. There are often two garters worn, one for tossing and the other as a keepsake. After the bride tosses her bri

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

al bouquet, which will be explained shortly, the groom will sit the bride down in a chair and remove the garter. Depending on the personality of the groom, o

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

r on how much he’s had to drink, this can be done quite seductively. Many grooms actually remove the garter with their teeth! In ancient times, the removal o

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

the garter by the groom symbolized the bride’s relinquishment of her virginity.

The groom then tosses the garter into the crowd of single men at the recept

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ion. The lucky one to catch it gets to place it on the leg of the woman, or girl, who caught the bouquet. Those who catch the garter and the bouquet are said

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

to be the next to marry, often to each other. The tossing of the garter, like the tossing of the bouquet, symbolizes good luck for the couple.

Tossing the b

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

ridal bouquet to the single women at the reception is a popular tradition. Most times the wedding bouquet that is thrown is actually a “throw away” bouquet t

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

at is made especially for this purpose. When silk wedding flowers are used, the bouquet can be treasured forever!

Other traditions include:

* Throwing rice

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

– this represents wishes for fertility for the couple.
* Unity candle – with two flames becoming one, this is symbolic of…well, unity.
* The weddi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

g kiss – when the groom finally gets to kiss his bride, this symbolizes the swapping of their souls.
* Wearing the ring on the third finger of the left

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

hand – wedding rings are placed on what’s known as the “ring finger” because ancient Greeks believed that there was a vein in this finger that led directly t

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the heart.

Of course, the tradition of carrying a bridal bouquet is one that will always be in style! And with today’s exquisite silks, carrying silk w

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

edding flowers is gaining in popularity! With all of the advantages of silks, using fresh flowers for wedding bouquets may someday become a thing of the past

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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