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The Magic Numbers

There is an amazing technique that changes the skills and attitudes math students. It teaches student to understand math in a whole new way. For those students wh

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

o count fingers to solve simple addition questions or students who count sets (8 + 8 + 8…) for simple addition questions, math becomes easy. In any given class there are one third o

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

the students who struggle with math and another third who are completely lost. This technique, if done properly, lifts these students to a level of understanding that changes how th

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

y look at numbers.

The technique works with all students, save those with severe disabilities or behaviour problems that the technique can’t be applied. It is geared for students in

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

grades three and four, since this is when they start learning the basic facts and early enough that they haven’t learned any bad habits that are difficult to undo. It does work with

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

lder students, but the closer they are to adulthood, the more difficult it is to have them apply the technique. It works with younger kids, even those as young as five or six years o

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

d. It is actually more beneficial to learn when they are younger as they grow up with the confidence and skills in math. It is also great for the self esteem when a six year old can

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

recall the times tables, something that usually isn’t mastered until grades five or six. Even then, only a third of the class will have learned them.

Once they learn these skills, t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

e rest of math becomes easy. The numbers are out of the way, so they don’t tumble around in the mind taking up valuable energy. They can focus on the concepts rather than counting f

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ngers. They way the learn them also gives them a better understanding of the numbers as they apply to real life situations. It simply makes math fun.

So how does this technique wor

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

? It is actually very specific, precise images that you help students create in their mind. Think of an engine of a car. Even though it is easy to drive, the engine is a complex de

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ign of parts that work together to create energy. The same is true of the images used to teach math called the Magic Numbers. They are specifically designed images that come from mn

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

monic research, key math patterns and mental connections that adapted from years of in class experience. Simply put, they are images that connect numbers to things children can relat

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

to and remember.

Imagine a tricycle representing the number three. The shape of the handlebars looks like a number three (for visual learners). There are three wheels (for kinesth

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tic learners). It is also called a three wheeler (for auditory learners). The tricycle is easy to imagine and fun to use which makes it easy to connect with other numbers using imag

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s. The tricycle can then be a part of a mental image that is crystal clear and easy to remember.

Even though this technique works amazingly well, it is at times difficult to convinc

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

adults of its success. Adults, especially teachers, question and analyze new techniques and are often skeptical of the results. I have often asked parents to simply watch while I w

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

rk one on one with the students without asking questions for at least one hour. Once they see the results, they no longer need to know why it works.

Not everyone will have an opport

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

nity to learn this technique, but it should inspire those searching to think outside the box. Although it is a technique that goes against traditionally learning, it works. It was f

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

und out of necessity and develop through success. For parents who have children who struggle in math or for those who want to ensure success in math down the road, there is an answer

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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It is one of the ironies of American history that Paul Revere should be best remembered for a horse ride he never completed - and which triggered a war that might never have happened had he not galloped about in the night alarming the countryside. Of greater significance, and a triumph of horsemanship, was another ride a year earlier by Revere in 1774.

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