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Uri Geller is, without a doubt, one of the most famous psychics in the world. His primary claim to fame is the bending of spoons using only his mind. Most of us have seen him do this

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

on television. But is it real?

No, it isn’t. It wasn’t. It was all parlor tricks. That was proven in a court of law and Mr. Geller has the empty pockets to show for it.

But wha

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

makes us believe a man like this? How did he gain so many followers? How did he even fool a team of scientists at Stanford Research Institute, which pronounced Geller such a gifted

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

sychic that they invented a term to describe his powers, the “Geller effect”? The bending spoon or key trick is accomplished by bending the object beforehand. Then during the show, i

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t was all in the angles he revealed. At first, he’d show the object with the bowl or flat side facing out and the bend wasn’t visible to the audience. Then he’d start rubbing and slo

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

ly revealing the bend, as if he had just made it happen, when it had been there all along. Sound easy? It’s not. It took him years of practice. Witnesses would claim they had neve

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

taken their eyes off him, but never saw it. Video tapes showed he distracted these people just long enough to make whatever adjustments he needed.

He had other tricks that seemed to

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

fool people endlessly, even though they see the same kind of tricks hawked at fairs. He’d “see” a drawing inside a sealed envelope by secretly holding it up to the light. He’d copy

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

own license plate numbers and car models from the parking lot of his shows to later amaze their owners with his psychic car-matching abilities. He’d ask audiences to bring in old, sto

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ped watches and he’d make them run. Many times shaking a broken watch will make it run for a short time and this is what he banked on. He could always find one of those. Within a fe

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

hours or days, it would stop again. But in the meantime, he was “amazing”.

So why do simple parlor tricks fool even intelligent people into thinking they’ve seen magic? As one astu

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

te writer said, “Because even many intelligent people are too foolish to realize that they are not so intelligent as to be beyond being fooled”. But think about this – if there ARE pe

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ple with the ability to move things with their minds; or read other peoples’ thoughts; or see hidden objects; or predict the future, why are they messing around entertaining us? Why w

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

uldn’t they be playing the stock market, working the casinos, finding a cure for cancer, or changing the course of rivers to put out forest fires? Easy. That would take a little more

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

than simple distraction.

There is something mysterious about a man who has made a career of breaking things! Sure, he can bend ‘em, but can he straighten ‘em out again? If so, I’ve

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

got a bunch of bent up silverware in my kitchen drawer for him! But this very mysteriousness attracted detractors.

James Randi, a famous debunker of the paranormal and a magician him

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

elf, was constantly in battle with Uri Geller. As many times as Geller demonstrated his amazing abilities, Randi was right there behind him to give an interview on how the trick was d

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

one. Eventually, he and other detractors convinced the public of Geller’s fraud. Randi’s point that this would have been accepted by everyone if Geller had just been honest in that h

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

was an entertainer, not a supernormal psychic was well taken. Law suits were lost and Geller, you’d think, would have slowly faded into history.

But today Geller has his own web pag

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

where he tells his own version of his talent. There he sells products in the lucrative New-Age self-help/personal growth industry. He may not be a psychic, but he landed on his feet

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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