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Full of Articles - 10 Amazing Facts about Dinosaurs
We're all familiar with dinosaurs from movies such as Jurassic Park and King Kong, but how much do you really know about dinosaurs? Here are 1
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
0 facts about dinosaurs which you can amaze your friends and family with:
1. Dinosaurs first appeared during the Triassic period (248 to 213 m
1. Dinosaurs first appeared during the Triassic period (248 to 213 m
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
llion years ago), and were the dominant land animals through the entire Jurassic period, and to the end of the Cretaceous period (65 million ye
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
rs ago).
2. We know about dinosaurs because fossils have been found. The fossils, which are generally found in sedimentary rocks, including fo
2. We know about dinosaurs because fossils have been found. The fossils, which are generally found in sedimentary rocks, including fo
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
silized body parts (bones, teeth, skin, claws, etc.), as well as trace fossils ("ichnofossils") which show how the animals lived, which include
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
footprints, burrows, nests, toothmarks, dung, etc.
3. The earth's continents slowly move through a process known as "plate tectonics". When d
3. The earth's continents slowly move through a process known as "plate tectonics". When d
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
nosaurs first appeared during the Triassic period, all the earth's continents were joined together in one super-continent known as "Pangea".
4
4
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
. All the familiar types of dinosaurs, died off at the end of the Cretaceous period. There are many different theories why this may have happe
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
ed, but today the most popular theory is that an asteriod hit the earth, blocking out the sunlight so that there was not enough food available.
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
Evidence for this theory is a layer of iridium, which is believed to have come from the asteroid, has been found around the world, and a possi
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
le impact site found in southern Mexico.
5. The smallest known dinosaur is Compsognathus, which lived in Europe during the late Jurassic, and
5. The smallest known dinosaur is Compsognathus, which lived in Europe during the late Jurassic, and
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
as about the size of a chicken. Compsognathus is believed to have eaten insects, lizards and other small animals.
6. There are quite a few can
6. There are quite a few can
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
idates for the largest dinosaur, as there are several types of dinosaur that were over 100 feet (30 metres) long. The largest was certainly so
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
e kind of sauropod (a four-legged plant-eating dinosaur with a long neck) that lived during the late Jurassic or early Cretaceous period.
7. T
7. T
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
he word "dinosaur" was coined by Sir Richard Owen, who also founded the Natural History Museum in London, England. "Dinosaur" means terrible
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
izard, and is based on the Greek words "deinos" (terrible) and "sauros" (lizard).
8. People have been finding dinosaur fossils for hundreds of
8. People have been finding dinosaur fossils for hundreds of
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
years, but didn't know what they were until quite recently. The first time that a dinosaur was scientifically described was in 1824, by Willia
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
Buckland.
9. At the same time that dinosaurs dominated the land, there were many aquatic reptiles that dominated the seas, although these wer
9. At the same time that dinosaurs dominated the land, there were many aquatic reptiles that dominated the seas, although these wer
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
not dinosaurs. These aquatic reptiles included plesiosaurs, nothosaurs, mosasaurs and ichythosaurs.
10. Although birds seem to have evolved
10. Although birds seem to have evolved
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
rom dinosaurs, no non-avian flying dinosaurs are known. However, at the time of dinosaurs there were many flying reptiles, known as pterosaurs
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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