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Turn your home into a magical world of scientific exploration and let your child develop his senses, his concentration and his vocabulary while having lots of (messy) fun. It just takes a little imagination and time to turn your kitchen or bath

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

into a learning experience for your littlest ones - and everyone gets to have fun in the process!

Pre-school children need plenty of time to feel, smell, think and explore. Remember that they can become easily overwhelmed, especially if they st

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

art out tired. Use the ideas below to gather together collections from around your house, trying to provide contrast and interest without over-stimulating. Supervise your child carefully at all times - and join in while he explores!

Water:

You

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

g children can play for a long time with water. Gather a collection of utensils - small buckets, scoops, spoons, pots, plastic beakers, whisks, sieves and so on, checking them carefully for safety. Then fill up a large dishpan or other container

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

with warm water, sit it in front of them on a towel, and let them have fun! If you include plastic jugs and bottles you can do all sorts of volume experiments. Ask questions! Which jug holds more water? How many cups of water do you need to fil

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

up the big bottle? Can you fit all the water in the big bottle into the little bottle? Why not? What happens?

For obvious reasons, this is a good activity for summer afternoons in the garden! Put a picnic rug on the grass and enjoy.

Touch:

F

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ind a collection of objects which will provide contrast for your child - a smooth towel, a soft teddy, a hard brick, a shiny metal spoon, and so on. Hold them against your cheeks, bang them on the table, sort them and enjoy them! Ask questions,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

nd develop vocabulary as you try this, using color words and other descriptive words according to your objects.

Extension - shut your eyes and explore!

Further extension - make a "feelie bag" out of a drawstring bag or an old pillowcase and en

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

courage your child to guess what is in it by feeling the objects only.

Smell:

Spend some time concentrating on smells! Go for a walk outside and smell the grass, the flowers, the leaves, the bark, the wind, the rain, the sun. Walk around the h

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

use and look for smelly objects. What smells good? Soap? What smells bad? The bin? Smell each other! Do smells change if you have your eyes closed? What about if you open your mouth?

Extension - "Smell Jars". Collect together some small contain

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ers such as film canisters or small plastic bottles. If necessary, cover the outside with a strip of card. Put a small piece of cotton wool inside and add a smell - perhaps lemon juice, lavender essential oil, washing up liquid, dried rosemary.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

Don't use anything toxic! See if your child can identify the smells. Which do they enjoy?

Hearing:

Spend a fixed amount of time concentrating on the sounds around you. Is it really quiet, or can you hear birds, traffic, neighbors, animals, pip

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

work, breathing? Do sounds change if you shut your eyes? What about if you open your mouth? Can you hear yourself? What sounds can you make?

Gather some objects together and see what noises you can make with them. Try kitchen objects such a woo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

den spoons, saucepans and plastic containers. Make sure you add some "quiet" objects such as fabric, paper or tissue so that your child can experiment with those too.

Extension - make some "musical instruments" out of cardboard boxes, dried bea

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

s and rubber bands! Try greaseproof paper folded over a plastic comb (a "harmonica") or a set of drums using cardboard boxes and wooden spoons.

Making Mixtures and Potions:

My son's favorite activity as a toddler was making potions - actually

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

it was one of the only things that would keep him occupied for more than 10 minutes at a time! Find an assortment of containers and then fill them with bits and pieces from the kitchen. This is an especially useful activity if you find dry goods

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

which have passed their use-by date! Think about lentils, dried peas and beans, rice, dried herbs and so on - try to get a good variety of sizes and shapes and even smells. Powdered poster paint can be fun too, in small quantities. Give your chi

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ld a tray and some empty containers, and a few utensils to stir with, and see what happens. Many children will stir their mixtures around very happily - it is strangely therapeutic!

After a while, if you are feeling brave, you can add a few mor

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

liquid ingredients to the mix! Try washing up liquid, colored water or even a little milk. Make sure that you supervise at all times, and warn your child that nothing goes in the mouth! If you added poster paint in the last stage, things will g

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

et quite coloring now! Obviously you usually end with a big sticky brown mess - but this is all part of the fun. If you need to rescue the containers and utensils, empty out the worst of it into the bin and then let your child wash everything up

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Media attention, the positive kind, can generate all kinds of sales for you. When one of your prospects sees you in a newspaper, magazine, or on television it paints you as an expert in that industry. Wouldn't you like to see yourself in that picture?

How should your resume show your faith? Contrary to what you might've been told, your resume should have your faith IN it, not ON it. That should be easy to do.

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