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When you think of acne, spots and pimples often come to mind, and you automatically assume that acne is simply acne, and that it comes in only one form. However, you may be surprised to find out that ther

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

e is actually more than one type of acne. In fact, there are quite a few! So how can you tell the various forms apart, and how do you know which kind you actually have?

The Different Types of Acne

Even th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

ough pimples are the most common form of acne, there are other forms too, and they are generally separated into groups which are non inflammatory acne and inflammatory acne.

Non Inflammatory Acne:
Non

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

inflammatory acne generally comes in two forms. Either closed comedo/whitehead or open comedo/blackhead.

An open comedo/whitehead usually occurs when the blocked follicle stays underneath the skin. The le

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ion is called a closed comedo or a whitehead and they usually appear just under the skin as small, white bumps.

A closed comedo/blackhead occurs when the plug enlarges itself and pushes through the surface

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

of the skin. They are generally dark in appearance because of built up melanin, not dirt as most people think.

Inflammatory Acne:
Inflammatory acne comes in a variety of forms and these are the type

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

s of acne which cause the most problems.

The mildest type of inflammatory acne is the papule. This appears on the skin as firm, small, pink bumps and they are often tender to the touch. They are often refe

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

red to as an intermediary between clearly inflammatory and non inflammatory lesions.

Nodules or cysts are another type of inflammatory acne and they are usually extremely large and painful. Nodules are gen

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

erally pus filled lesions which are lodged deep into the skin. They usually develop when a comedo has spilled into its surrounding skin and the immune system responds by developing pus. If the nodules last

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

for quite a long time, usually at least a few months, then they can turn into cysts which can be particularly nasty. If you do have nodules or cysts, they do tend to leave scars.

Pustules are small, round

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

haped lesions, and they are very similar to papules. They are usually really inflamed and it is also possible to see that they filled with pus. The inflammation of a pustule is not due to bacteria, it is si

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

mply due to a chemical irritation from sebum components like fatty acids for example.

Acne Conglobata is the final type of inflammatory acne and it is generally the least common type. However, it is one of

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

the most serious forms of acne and it is usually found either on the back, chest and buttocks. As well as Pustules and nodules being present, there are also a lot of bacteria there too which can cause a lo

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t of problems!

Overall the most common form of acne is Acne Vulgaris and that contains both whiteheads and blackheads. It is the easiest form to treat and usually Benzoyl Peroxide is the best treatment met

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

od available for it.

So how do you treat the other forms of acne then?

Treating the Different Forms of Acne:

All forms of acne generally get worse if you keep touching them, and so the first step to trea

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ting the condition, is to touch it as little as possible. Most acne treatments available are good for all acne types, and things such as essential oils will really help. The best ones to try are tea tree oi

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

l (which is actually contained in a lot of acne treatment products), and witch hazel.

If you want to try over the counter products, Benzoyl Peroxide is generally the best ingredient to go for. Usually good

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

acne treatments are fairly expensive but it will be well worth the money in the long run as you will not end up wasting more money on products which claim to work miracles but which actually do not work at

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

all.

The best way to know which treatment method is better for you is to visit your doctor who will be able to give you a proper diagnosis and advise you on what will work better in your individual circums

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

tance. Do not expect instant results with whichever treatment you do end up using, usually results take up to around six months to show fully. Overall you can beat your acne, but you just have to be patient

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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