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Many asthmatics have severe aggravation in their condition due to allergies to certain allergens. Common allergens causing asthma are:

Plant Pollens: Pollen grains are the powdery substance produced by the plants for the process of reproduction. Individual pollen g

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

rains are very small in size so collectively they appear as a powdery substance. Pollen grains of different plants are of many different shapes and sizes. They get disseminated by wind, water or animal sources to far and wide places. Some people are allergic to pollens of

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

some plants. Since the pollen emergence is seasonal their allergy is also seasonal.

It is mostly seen that the pollen that get disseminated with wind cause allergic asthma in people. Generally the flowers of plants that have wind disseminated pollen are unattractive in ap

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

pearance and smaller in size. Pollens are generally released early in the mornings, often before sunrise. Many patients who are sensitive to them also develop symptoms around that time. For allergic people it is important to know the pollen calendar of a place before one h

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

s plans to settle down there, or is only visiting the place, if one is susceptible to pollen allergies. It is also recommended to keep the windows closed and prefer to be in air conditioned atmosphere.

Fungi: Fungi are saprophytic plants that are very small in size

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

. So they appear as fibrous growth on the surfaces they grow. They are basically scavengers and help in decay and break up of dead organisms into basic chemical components. Some fungi are very useful and are put to various uses. Antibiotics like penicillin and streptomycin

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

are made from them. Various mushrooms are fungi varieties. Alcohol, wine, cheese and various bakery products made by the process of fermentation are made by the use of many fungi. They propagate mostly by vegetative growth.

The spores produced in the process are released

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

as powdery substance. Some people are allergic to these spores. They cause allergic asthma in people. It helps to study the fungal calendar just as in the case of pollens. The peak periods of fungal spore concentration are the months of September to November and February t

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

o April. The people who are allergic to various fungi may show allergic reactions even after consumption of foods containing them. Mushroom allergy is known to be very common.

The people suffering with fungi allergies should take additional precautions apart from followin

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

g the fungal calendar. They should avoid any accommodation in basements of buildings whether for official or residential purposes. Plastered and painted walls should be preferred instead of wall papered ones, which may catch moisture faster. All rooms and spaces should be

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ery well ventilated. Potted plants should be avoided inside living spaces.

House Dust: Many people are allergic to house dust. The dust that settles over the various furniture and furnishings in the house is collectively called house dust. It may comprise of the ou

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

tside dust and also the various kinds of dust that originate inside the house. It may be from food remnants, from the pets, from insects in the house, from human hair and skin and many other such sources.

The house collects more in carpets, beddings, old furniture, and ot

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

her nooks and crannies. Normally such dust is not visible. It can be seen in the shaft of sunlight entering a room. The people who are allergic dust are actually shown to be allergic to mites occurring in the dust. The most common house dust mite is named Dermatopagoides p

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

teronyssinus. These mites live and feed on the components of the house dust. Those who are allergic to house dust should keep their living spaces scrupulously clean. They should avoid putting too much of furniture and heavy furnishings in their rooms.

Food Articles:
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
Many people are allergic to different food articles. Different symptoms may be caused in different people allergic to various foods like gaseous distension, diarrhoea, urticaria, headache, swelling of lips, sores in the mouth cavity and many others. Sometimes the symptoms
t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
appear immediately and sometimes they take a while to manifest. Also the food allergies may be dependent upon the seasonal changes. Many infants are allergic to milk especially cow’s milk. Wheat, fish, egg and mushrooms are common food allergens. The diagnosis is dependen
ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust
t upon elimination diets as skin tests are generally of not of much help.

Insects: Insect bites normally cause pain and swelling due to the introduction of insect venom inside the system. The degree of manifestation of symptoms depends upon the quantity of venom. T
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
e insects can be of two types the stinging insects and the biting insects. However the symptoms are never fatal. Some people are allergic to remnants of insects.

Animals: Many people are allergic to different animals among these most common ones are domestic animal
.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
s like cats and dogs. Other animals may be horses, cows, buffaloes and other fur bearing animals. The allergy is mostly caused by animal dander.

Occupational allergens: Many people are allergic to substances that they may come in contact on account of their occupat
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip
ion. Some common examples are bakers getting allergic to flour, cement workers allergic to cement, sulphur allergy in workers in different medicine factories, workers allergic to leather dust and hairstylists and beauticians allergic to various chemicals in beauty products

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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