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Medication has been around for centuries so it is not necessarily among the most current treatments of Depression. The current trend in medication is new classes of a

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

ntidepressants. They have less toxicity and side effects than previous types. There are newer classes of medication and new ones are being discovered all the time.

Th

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

e current trend in treating Depression is to prescribe a booster drug along with the primary antidepressant. The booster drugs are designed to enhance the effectivenes

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

s of the antidepressant. For example Cytonel, a thyroid stimulant is prescribed with an antidepressant. This approach works well about 50% of the time.

Hormone therap

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

y is another of the current treatments of Depression. It is believed that many women become depressed because they have imbalance of progesterone or estrogen. Progeste

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

one is about 7 times stronger than some Barbiturates and has a calming, sleepy effect.

Estrogen provides more energy and is said to be better than Prozac. The prescri

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

ption of either Progesterone or Estrogen will depend on where the imbalance of the two hormones lies.

If you are agitated, you may be given more progesterone. If you

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

are lethargic, you will likely get more Estrogen.

Vagal (Vagus) Nerve Stimulation - VNS is a procedure that is used to treat Epilepsy. In this procedure a tiny pacema

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

ker type device is placed in the chest and directed to a nerve that runs from the neck to the brain and thought to manage depression. A pulse is delivered along the Va

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

gal nerve at regular intervals to stimulate the brain and provide relief.

Magnetic Healing techniques also are used to stimulate the brains nerve cells. TMS or Transc

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

anial Magnetic Stimulation is performed by a doctor. A magnetic coil that is charged with electricity is passed over the scalp. The magnetic electric pulse passes thro

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

ugh the skull and stimulates the brain as was previously mentioned. This is a rather new and still experimental procedure. It has enormous potential for become very pr

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ecise in the future. It is possible according to some researchers that the TMS will replace the ECT - Electroconvulsive Therapy or shock treatments.

There is a trend

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

now to turn to herbal treatments - typically in the form of supplements. Specific herbs such as Chamomile, Hops, and Milk Thistle among others are blended in a specifi

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

c formula to address depression. In order to be sure the herbal supplements you are purchasing is of the highest quality possible, it should be made to pharmaceutical

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

rade. The metabolic pathways of the ingredients are examined at the molecular level and the interaction of the ingredients is also tested.

Be sure if you are conside

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ring using herbal supplements that you consult with your doctor especially if you are being treated for other health conditions with prescription medications. The herb

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

al supplement could reduce how effective the prescription medication would be.

There is a variety of current treatments of depression. You and your doctor can decide

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

together what protocol of treatment would best suit your particular needs. Depression is nothing you or anyone should be ashamed of; neither should you be ashamed of g

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

etting the help you need in the form of therapy, medication, or our route of choice – Natural supplementation with regular exercise and partaking in positive activates

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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