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Willow - Salix alba

Willow information and how it is used as a herb in alternative herbal treatments t

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

o treat ailments and problems, such as to break and bring down fever, rheumatism, arthritis and gout.

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

Although we believe in the therapeutic and healing properties of herbs, care must be taken in the use t

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

hereof, as they are powerful compounds.

Botanical Classification: Family Salicaceae

Genus and specie:

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

Salix alba

Other names:

White Willow or osier.

Description of the herb willow:

This large tree with

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

its deeply fissured bark and hanging branches are a well-known site in river and wetland areas.

Parts

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

used:

The bark is normally used, although the leaves can also be used.

Properties:

It is a bitter,

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

astringent herb with cooling properties, which relieves pain, lowers fever and reduces inflammation.

I

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

contains phenolic glycosides, such as salicylates (salicortin, salicin, tremulacin), syringin and tria

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ndrin, as well as phenolic acid (chlorogenic acid) and oligomeric proanthocyanidins.

Therapeutic uses:

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

Internal use:

The bark and leaves are very effective to break and bring down minor fevers and colic.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

The bark is most helpful to treat rheumatism, arthritis and gout, as well as diarrhea and dysentery,

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

eadache and neuralgia.

The pain relieving action as analgesic is due to the inhibition of prostaglandi

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

n synthesis by the salicin derivatives, which cause sensitization of peripheral pain receptors, and "na

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

tural aspirin" from the willow bark seems to have far less side effects than the synthetic aspirin made

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

by pharmaceutical companies.

External use:

Willow bark extract has shown excellent results when deal

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ng with acne and problem skin. This also works as a beta-hydroxy acid, and is included in various cosme

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

tic products for this purpose.

Aromatherapy and essential oil use:

None noted.

Safety precautions an

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

d warnings

No parts of the willow should be used by people who are sensitive to aspirin (salicylates)

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

although the natural aspirin contained in willow is deemed to be less irritating than synthetic aspirin

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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