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Full of Articles - Tai Chi Breathing Reduces Residual Air in Ineffective Retention Space
Breathing is the source of life: if breathing stops, do does life. On average, an adult breathe 16-18 times per minutes, each time about 500ml of air exch
According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product
anged in the lungs. When breathing in from the outside air, oxygen content is about 21% while carbon dioxide is 0.03%. On the other hand, breathing out produces about 1
; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.
Examples of combination products may in
Examples of combination products may in
.5% oxygen and 4.5% carbon dioxide.
Based on the average of 16-18 breath per minutes, it can be estimated that the volume of air exchanged in the lungs is about 8000-9
Based on the average of 16-18 breath per minutes, it can be estimated that the volume of air exchanged in the lungs is about 8000-9
lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.
000ml. From this, the content of both oxygen and carbon dioxide exchanged can also be calculated.
In calculating the air exchanged, there’s a factor that needs to be c
In calculating the air exchanged, there’s a factor that needs to be c
here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe
nsidered: there’s about 150ml of air left in the Ineffective Retention.
What is Ineffective Retention?
Ineffective Retention refers to the space
What is Ineffective Retention?
Ineffective Retention refers to the space
d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.
Combination pro
Combination pro
etween the lungs and the nose, that is, the space in the nasal, throat, trachea, and bronchus which contains residual air of about 150ml. The residual air in Ineffectiv
ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc
e Retention has more carbon dioxide and lesser oxygen compared to the air outside.
Each inhale of 500ml of air from the outside will include this 150ml residual air in
Each inhale of 500ml of air from the outside will include this 150ml residual air in
easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi
the Ineffective Retention. This means the effective oxygen content in each inhale is in fact lesser than 21%! This means, for every minute, you will be taking in about
nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically
2400-2700ml of residual air in the Ineffective Retention space!
Active air volume in the lungs is very important. Thus, through deep breathing, achieved through
Active air volume in the lungs is very important. Thus, through deep breathing, achieved through
and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ
abdominal breathing – the air exchange in the lungs can be increased to 2000-6000ml, and at times, exceeding 6000ml!
And with deep breathing, which takes
And with deep breathing, which takes
ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi
longer time per breath. On average, if you do deep and slow breathing, you can reduce the rate of breathing to 9 times per minutes, taking more than 2000ml of ai
ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.
Following aspects would a
Following aspects would a
r per inhale. This will in effect, reduce the number of times where the 150 ml of air in the Ineffective Retention going back into the lung. This means that only 1350ml
dd to the challenges in developing combination products:
Which markets to tap where the combination products can do fairly well?
Which combination prod
Which markets to tap where the combination products can do fairly well?
Which combination prod
of residual air going back into the lung exchange, but fresh air exchanged is more than 18000ml per minute!
This increases oxygen intake significantly. B
This increases oxygen intake significantly. B
cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin
lood circulation and metabolism rate will increase, and immune system will be enhanced through deep, abdominal breathing!
This is another proof to show that Tai Chi Br
This is another proof to show that Tai Chi Br
tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
What would be the developing cost?
How to tackle the risks encountered during combination product developmen
athing has its scientific logic and reason for improving your health conditions and mental well-being. However, the data above showed how health can be improved by deep
t?
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel
abdominal breathing alone only.
My system involves 5 Steps of Tai Chi Breathing, and abdominal breathing is only Step 2 of the whole system, and on its on, has
My system involves 5 Steps of Tai Chi Breathing, and abdominal breathing is only Step 2 of the whole system, and on its on, has
ping new procedures for reviewing their safety, efficacy and quality.
Professional from academic institutions, pharmaceutical industries, health care indust
Professional from academic institutions, pharmaceutical industries, health care indust
shown such tremendous effect on your body health. What about other steps? And if you are interested in learning how to do Tai Chi Breathing correctly, and to make it yo
y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products
r habit, go to my website under my signature and find out how.
And may the Energy of Tai Chi be with you! :)
Breathing cheerfully,
C. Guan Soo
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
And may the Energy of Tai Chi be with you! :)
Breathing cheerfully,
C. Guan Soo
.
As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de
ew" Href="http://www.TaichiBreathing.com">http://www.TaichiBreathing.com
Copyright (C) 2005 C. Guan Soo
*************** Note ***************
You may dist
Copyright (C) 2005 C. Guan Soo
*************** Note ***************
You may dist
elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.
Companies that provide selfless information through particip
Companies that provide selfless information through particip
ibute or publish this article freely provide you do not make any changes or alteration on the article content, or remove my name and website from the article. Thank you
tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products
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