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If you were to count all the synapses in your brain, pointed out Nobel-prizing winning neuroscientist Gerald Edelman, it would take more than 32 million years.

The number of possible neuronal circuits in your brain is even more astoni

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

shing: 10 followed by 1,000,000 zeros.

To put this into context, the number of particles in the known universe is 10 followed by 79 zeros.

Ironically, despite this enormous potential, many people not only discount the power of their

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

brain, but they fail to keep it in shape.

The myth that the amount of intelligence you have developed as an adult is somehow fixed has long been discounted in science. Research now shows that the brain is plastic. Just as when you e

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

xercise, you develop more muscle fibers, so, too, when you use your brain more, you develop more neuronal circuits.

When you learn something new, your brain changes. New connections are formed. As you learn more and more about a sub

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

ect, the thicker these connections, until you have a trunk line and some level of mastery on that subject. However, when you discontinue learning about that subject, those connections atrophy.

This is why an adult may know a lot less

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

about a certain subject than someone in High School, even if they had studied the same thing. The brain of the High School student is developing connections, while the adult brain is atrophying them.

Physical fitness is something you

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

notice right away. You know when you are out of shape. You can see it, feel it, sensate it. With the brain, it is more subtle. You have a tendency to forget more often. You are only interested in simple books and programs because

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

you find comprehension a challenge. You think learning new things is boring. All these are symptoms of an out-of-shape brain.

It is not necessary to be older either to have an out-of-shape brain. Many people in their twenties, fed

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

n a diet of superficial conversations, undemanding media exposure, and a disdain for any intellectual pursuit, show all the symptoms of inefficient brain functioning.

Age is often used as an excuse to neglect your brain. Again, anoth

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

er myth is responsible for it. The myth is that your brain is in a gradual state of atrophy. Your brain cells like your physical cells are aging rapidly. Actually, even if this were true, there is such an abundance of brain cells th

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

t it should not even make any noticeable difference.

The brain is plastic and it grows with use. The older you are, the more chances are that you have built a significant neuronet of ideas. It is actually possible to grow smarter as

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

you grow older because you have more associations built up in your brain and therefore it is easier to grasp something. You don't have to start from scratch. You have internal references in place already.

Even after a neuronet on an

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

y subject has atrophied due to neglect, it can quickly be restored. Just as muscle-memory allows an out-of-shape athlete to get back into shape with exercise, so too does restudying your favorite subject quickly make you an expert at

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

t again.

The most powerful youthing formula is doing mental exercises. Studies have shown that those seniors who play chess, card games, solve puzzles, or pursue an interesting hobby, not only have a great attitude, but they are also

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

biologically younger than others of the same chronological age.

The idea that you get dumber as you grow older, it is just not true. Those who are considered "knowledge workers" are as sharp in their older years, then when they were

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

younger. Einstein, for example, was still working out problems in Physics on the day he died.

In some older cultures, wise men are portrayed as old. They are imagined with long white hair and long white beards. In those cultures th

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

y understand that an older person has had more time to learn more things.

In Western cultures, older people are portrayed as senile. They are tolerated, rather than respected. This new archetype is a destructive one. Those who embr

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ce it, even unconsciously, come to live it out.

Senility is a condition of atrophy due to brain neglect. This neglect eventually results in some form of physical manifestation, a variety of organic damage and dementia.

Senility is n

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

ot a symptom of old age, but a symptom of prolonged neglect.

Getting your brain in shape is a lot easier and faster than getting your body in shape. Your brain does not tire and it grows fitter faster.

It is not possible to lead a f

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ll, significant, and happy life if you are in poor mental shape. The good news is that all it takes to become an interesting, vibrant, and progressive person is to start to exercise your brain.

It's never too late to have a fit brain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Getting the attention of the customer is the only way a company can survive. Since there are other brands competing, it is important to advertise in order to gain leverage over the others. A company can spend a lot of money on television, radio or the billboards but if there isn’t enough money in the budget it is best to use advertising balloons instead. The practice of using this in the United Kingdom is almost the same as in the United States.

Middle managers are under pressure from upper management to produce financial gains at the same time they are being squeezed by lower level employees who are looking for more input and growth. That middle managers face the same worries and misgivings as regular employees and frontline supervisors and managers shouldn't be a shock . . . except . . . I have a feeling that these are the people who can actually do something about the general work environment.

Looking for ideas to open more prospects' doors, this article is loaded with the kind of amunition you need to bring in more new customers.

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