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Muscular and joint pain can affect anyone from the age of eight to eighty. These pains may be cause by exercise, injury, rheumatism and arthritis,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

or just general wear and tear on the body. at other times pain may be cause by repeating the same movement over and over, which is called repetitiv

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

strain injury [RSI]. This can occur through exercise or routine activities at work.

SPRAINS AND STRAINS.
sprain are injuries to a joint or it

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

associated structures and usually occur as the result of a sudden forceful movement. These result in pain, swelling and limited movement. Strain a

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

e injuries to a joint and may be cause by exercise stretching of muscles or by not warming up properly before exercise. Strains usually result in s

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

abbing pains in the area of injury and swelling.

SPORTS INJURIES
many people take part in sporting activities to improve their health make th

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

m feel better or just for enjoyment. However exercise can put extra on muscles ligament and joint especially around the legs and back. Muscle pains

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

often occurs due to overexertion during exercise or from not warming up before or colling down properly after exercise can also help prevent injury

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

SIGNS And symptoms 1 [pain and stiffness in a muscle or joint especially when moving around 2] pain, swelling or bruising of a joint sometime accom

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

anied by heat

TIPS TO AVOID INJURY
1]reduce the number of days of consecutive training to give muscles an opportunity to restore and repaired

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

themselves between work-outs.
2]relax, Tension may make muscles and tendons taughter increasing the risk of injury during work-outs.
3]st

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

rengthen muscles through resistance training to make them less susceptible to damage
4]warm up fully with slow, controlled stretching of muscl

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

s.
5]Avoid training when tired.
6]increase consumption of carbohydrates during heavy period of training.
7]if you experience pain ST

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

P training immediately
8] never train hard if you are stiff from the previous session
9]Make sure you are properly hydrated
10]Intro

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

uce new activities very gradually
11]shower and change immediately after cooling down
12]Have regular sports massage

if an injury do

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

s occur, follow the RICE principle for the first2 or 3 days -rest, ice, compression and elevation of the injured muscle, this aim to stop the bleed

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ng in the muscle, minimize swelling, prevent further injury and promote healing

MUSCLE PAIN AND STIFFNESS muscle pain and stiffness becomes more c

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

mmon as people get older. The pain is fairly generalized and can occur anywhere although more frequently in the shoulder, neck, back legs and knee.

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

Feeling of stiffness may be worse after periods of inactivity such as after sitting down or on waking.

TIPS FOR TREATING MUSCLES AND JOINT PAIN AT

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

HOME.
1]Massage the area and keep it warm
2] Take warm baths
3]Rest
4]stretch out muscles
JOINT PAIN
1]Rest sore join

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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