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Have you ever ridden on a roller coaster and felt like you were out of control? LIFE can be like a roller coaster for those of us with Arthritis. There are good days and

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

bad days. It is what we do with what we have—that counts.

Arthritis affects nearly 70 million Americans. There are more than 100 types of arthritis including rheumatoi

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

d arthritis and degenerative arthritis. There are numerous arthritis treatments to help manage the pain as well. Arthritis is a major cause of chronic pain and leading ca

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

use of disability in the United States.

Did you know that the word arthritis literally means “joint inflammation?” Inflammation and pain are involved in most types of ar

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

hritis. Aching, throbbing, nagging, sometimes sharp pain – arthritis hurts!

It can make simple, daily activities like opening a pill bottle, getting out of a chair or ev

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

en walking difficult. There is no cure for arthritis but there are things you can do to help manage arthritis pain symptoms.

See your doctor: Know what type of arthritis

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

you have. Early diagnosis is important to proper treatment and prevention of permanent joint damage. Follow your doctor’s advice.

Keep a Positive Attitude: Make a pla

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

n for managing your arthritis. Take control. Arthritis is a condition that requires your participation in ongoing care.

Control your weight: Increased weight adds stre

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

s on joints in your back, hips, knees and feet. Less weight will reduce this stress.

Exercise: Stay fit! Exercise regularly to build muscles and keep joints moving wel

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

l. Inactivity can increase your weight gain and your pain. Exercise (even walking 30 minutes a day or 10 minutes 3X a day) can increase strength and stability in weakene

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

d muscles and mobility in your joints. Remember the saying “Use it or lose it” – Then MOVE it!

Relax your muscles: Stress increases muscle tension, pain and feelings of

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

helplessness and depression. Try relaxing by tensing and releasing muscle groups. Start at your head and work down to your toes. Deep breathing also helps to reduce st

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

ess.

Use assistive devices: Specially designed tools, called assistive devices, can help you perform basic activities. Long handled reachers, padded cooking utensils, e

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

tc., are available in stores, catalogs, and online.

Avoid improper positions: Using good posture and good body mechanics will help protect your joints. Don’t slouch in

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

your chair; keep your head, neck and back straight, your legs uncrossed and your feet on the floor. This will help you reduce unnecessary pain.

Move around: Don’t stay

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

in the same position too long. Taking frequent stretch breaks will reduce joint stiffness and pain.

Respect your Arthritis pain: Pain is a signal from your body that so

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

ething is wrong. Arthritis causes some chronic pain, but when you have sudden excessive pain after an activity, you may have overexerted yourself or have been doing the a

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ctivity incorrectly. Listen to your body, learn your limits and take extra care when you have pain.

Know your limits: Rest when you are tired. Arthritis can cause fati

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

gue muscle weakness – a deep exhaustion that makes everything you do a great effort. Give yourself permission to rest. Pace yourself – don’t overexert yourself on one pro

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

ject. Break jobs down into smaller pieces that you can do over a period of time with rest breaks.

With proper attention to these items you can manage your arthritis pain

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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