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Sigmund Freud was one of the most influential people of the 20th century. He claimed that depression and anxiety are influenced by factors that affect us in childhood,

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

and that interpreting dreams can lead us to the childhood causes. He felt that psychotherapy could make emotionally sick people heathy by getting them to understand tha

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

t what happens in childhood can cause them to develop depression, anxiety and schizophrenia.

For 50 years, Freud was one of the most revered scientists on earth. Then

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

cientists discovered neurotransmitters, chemicals that pass messages from one nerve to another. They found that people who hallucinate and are not able to think clearly

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

are schizophrenic because their brains make too much dopamine or glutamate; that people are depressed because their brains make too little norepinephrine and serotonin

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

that people who shake with Parkinson’s disease do so because their brains make too little dopamine; and that people who lose their ability to reason and remember becau

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

se they suffer from Alzheimer’s disease have too little acetyl choline. So now these diseases are treated with drugs that raise or lower brain levels of neurotransmitte

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

s. Drugs, like Mirapex, raise dopamine levels to treat Parkinson’s disease. Drugs such a Paxil, Prozac, and Zoloft to raise brain levels of serotonin and treat depressi

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

on. Modern psychiatrists know that you cannot treat chemical depression, schizophrenia or anxiety just with talking. You treat mental disorders with drugs to correct ab

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

ormal brain levels of neurotransmitters.

But wait a minute. Because today psychiatrists treat depression, anxiety and schizophrenia with drugs, doesn't mean that Freud

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

was wrong. Psychiatrists cannot talk people out of mental disease, but new scientific marvels called pet scans, electroencephalograms, MRIs and so forth show why Freud

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

was right. When you go to sleep at night, your eyes are still. After a while, your eyes dart from side to side rapidly. This is called Rapid Eye Movement sleep or REM

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

or short, and during REM you have dreams. If you wake up, you can report your dreams, but if you try to remember your dream a few hours later, you usually can’t. Durin

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

g REM sleep, the part of your brain that governs emotions and visual imagery are activated, while the part of you brain associated with rational thought and reasoning a

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

e turned off. So dreams may uninhibit you so you can think about things that may be too painful to think about when you are awake. Or dreams may allow you to discover t

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

hings about yourself that you would never tell directly to anyone, let alone your doctor.

So, 100 years after Freud published his Interpretation of Dreams, we can see

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

hat he may be right because dreams can be a clue to why we feel depressed, anxious and may reason poorly. But psychotherapy, by itself, has not been shown to be an effe

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

ctive treatment for most cases of depression, anxiety or schizophrenia. On the other hand, psychotherapy plus medication is more effective than medication alone to trea

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

anxiety and depression. Psychotherapy can help people cope better with their problems and interpreting dreams can help them understand why they are what they are. Even

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

though many theories proposed by Freud one hundred years ago appear to be wrong, Freud remains one of the most brilliant contributing intellectuals of the 20th century

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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Full of Articles - Dreams and Depression: Was Sigmund Freud Correct?

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