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It wasn’t just media news that caused supplement companies to begin looking for hoodia gordonii supplies. By researching hoodia Phytopharm, a British pharmaceutical company caused the i

According to USFDA, a combination product is one composed of any combination of a drug and device; biological product and device; drug and biological product

nitial stir of interest. Phytopharm continues to release hoodia info to the press, but details are limited.

Phytopharm has two operating divisions; a plant extract division and a pharm

; or drug, device, and biological product and fixed dose combination would include two or more combinations of drug.

Examples of combination products may in

aceutical division. In June of 1997, Phytopharm released the first hoodia info to the press “a naturally occurring appetite suppressant is to be developed into a prescription medicine b

lude drug-coated devices, drugs packaged with delivery devices in medical kits, and drugs and devices packaged separately but intended to be used together.

Phytopharm”. They were talking about hoodia. Phytopharm sent supplement companies and those who needed to lose weight searching for this “naturally occurring appetite suppressant”. A

here is enormous increase in the number of combination products entering the market in the recent years. Combination products have proven advantages but fixe

t that time, everyone expected the extract from hoodia Phytopharm would develop would be a prescription drug. This hoodia info was supported by Phytopharm’s collaboration with Pfizer, a

d dose combinations are still in the process of convincing regulatory authority on their advantages over the single ingredient formulations.

Combination pro

nother pharmaceutical company, to research and develop a product made from hoodia. Phytopharm has now partnered with Unilever, since Pfizer returned the developmental and global marketi

ucts have become life saving products for the pharmaceutical companies who doesn’t have many innovative molecules in their product pipeline and have been inc

g rights after closing their division which dealt with plant extracts. Unilever is not a pharmaceutical company. They sell food, dietary supplements and make the Slim Fast products. N

easingly used in the product life cycle management. Even the companies having product patents are trying to extend their product life cycle through the combi

ow it is unclear what form the extract of hoodia Phytopharm is researching will take. The latest hoodia info from Phytopharm does mention that they are aware other companies are selling

nation products and maximize the revenues. But the companies involved in this practice are overlooking that they are burdening the patients both economically

hoodia gordonii products, but they seem committed to the idea that theirs will be superior.

To start with hoodia, Phytopharm began proof of principle testing in March of 2001. This f

and physically. They need to rightly judge the benefits of the combination products and they have to even look at the risks involved when combining the produ

rst phase was completed in December of 2001. The hoodia info released at that time stated that hoodia gordonii was a naturally occurring substance and there appeared to be no side effec

ts. Some of the combination products were well accepted by physicians while others suffered. Companies involved in development of combination products are fi

ts associated with its use. After completing the initial clinical testing of hoodia, Phytopharm began the search for a partner company for “late stage development, sales and marketing”.

ding difficulty in defining their combination products and facing various challenges from selecting a combination to marketing it.

Following aspects would a

This was how Pfizer and later Unilever became involved. Phytopharm is currently researching and investigating the possibility of a prescription drug to treat metabolic disorder and ho

dd to the challenges in developing combination products:

Which markets to tap where the combination products can do fairly well?
Which combination prod

dia gordonii is the basis for this drug. So, when it comes to hoodia, Phytopharm seems busy, but this is not the only products they are currently investigating. In addition to hoodia i

cts are meaningful and rational?
Which therapeutic categories to select?
Which Combinations can address unmet needs of the patients?
Do combin

nfo, Phytopharm’s press releases include info about two veterinary products, a treatment for Alzheimer’s disease, Amyotrophic lateral sclerosis and Parkinson’s disease.

The extract of h

tions increase the patient compliance?
What would be the developing cost?
How to tackle the risks encountered during combination product developmen

oodia Phytopharm’s is using for its research is patented, but they have had more than a little trouble keeping other manufacturers of natural products from selling their own hoodia gordo

t?

As combination products don't fit into the traditional categories of drugs, medical devices, or biological products, the USFDA is in the process of devel

ii products. In early May of 2006, they announced that they were aware that other companies were selling hoodia gordonii as an appetite suppressant and that they believed that this coul

ping new procedures for reviewing their safety, efficacy and quality.

Professional from academic institutions, pharmaceutical industries, health care indust

d be patent infringement. They said that they had contacted the appropriate authorities. Since then, the statement about patent infringement has been removed from their website. The p

y and representatives from various regulatory agencies are working out to design the regulatory requirements for manufacture and sale of combination products

roblem is that a plant can not be patented. According to Phytopharm’s hoodia info, there product will be unique, stronger, safer and better than the hoodia products that are currently o

.

As there is an increasing trend of the combination products companies manufacturing such products should be able to tackle the problems involved in the de

the market. In a couple of years, after completing the clinical research of hoodia Phytopharm is expected to release its hoodia gordonii product and consumers will be able to judge for

elopment. They need to be wiser in analyzing the market trends and the regulatory requirements.

Companies that provide selfless information through particip

themselves.

For the latest hoodia info, visit the Hoodia Info Blog

tion in industry events and feedback to regulatory authorities would be able to face the challenges and will be successful in developing combination products

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